Big Data is a new term used to identify the datasets but due to their large size and complexity, we cannot manage them with our current methodologies or data mining software tools. With the fast development of networking, data storage, and the data collection capacity, Big Data is now rapidly expanding in all science and engineering domains, including physical, biological and biomedical sciences. Big Data mining is the capability of extracting useful information from these large datasets or streams of data, that due to its volume, variability, and velocity, it was not possible before to do it. The Big Data challenge is becoming one of the most exciting opportunities for the next years. This paper represents a broad overview of the topic, Big Data challenges, Data Mining Challenges with Big Data, Big Data processing framework and forecast to the future