Drive shaft or propeller shaft is the essential part of Automobiles. It is used to deliver torque from transmission to the differential and further to the wheel to cause the motion of the vehicle. The drive shaft is used to connect with the transmission shaft with the help of universal joint whose axis intersects and the rotation of one shaft about its own axis results in the rotation of the other shaft about its axis. In present work the model of the drive shaft has been generated in Solid works and further imported in ANSYS workbench. A finite element analysis of the drive shaft has been carried out as a case study. In the present work the static analysis of a drive shaft has been carried out with the new design changes. The results for equivalent von-Mises stress, strain and deformation have been calculated by applying boundary conditions and compared with the existing results.