The study aims at designing an information system to enhance the registration of products with ease and effectiveness for NAFDAC(National Agency for food and drugs Administration and control) as a case study. This study emergesas a result of the shortcomings discovered in the registration of product in NAFDAC such as typographical error, time consumption, lack of durability and safety of tiles and inadequate manpower. To design the system, the mode of operation of NAFDAC was enquired with other vital details. The system is design to suit the needs of the users. It also describe the functionality imbedded in the product registration system application, the components, how it operates, its' relevance and future development. Visual basic 6.0programming language was used in other to achieve the required objectives. The systems has been designed, tested and implemented it successfully.